Return to Pharmacotherapy Update Index. Introduction. Currently, pantoprazole sodium (Protonix®) is the only proton pump inhibitor (PPI) available in the United States for intravenous (IV) use. Prevacid (lansoprazole) vs. Prilosec (omeprazole) With very similar pathways that deliver similar results, the major difference between these two medications is that Prilosec has been around for longer, and, therefore, has an extended safety record. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Fried on famotidine vs omeprazole.To what will help with a distended abdomen depends entirely on the cause of the distention. Probiotics are helpful with a lot of digestive issues, if you take them regularly. The two meds you mention reduce stomach acid and are. Learn about Prevacid (Lansoprazole) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. I took Omeprazole (generic for Prilosec) for 12 years when I found that I was having some horrible side affects such as Urinary Tract Infections, Sinus Infections, bone pain, shortness of breath, nausea in the morning, etc. (Click GERD Symptoms for a more complete list of potential symptoms of this condition and for an explanation of the difference between GERD and heartburn. Information on lansoprazole (Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid 24), a drug used to treat ulcers of the stomach and duodenum, gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety is included. There is no data that suggests a significant difference between Protonix and Nexium. Nexium is an appropriate appoach to Barrett's esophagus. Headache was also seen at greater than 1% incidence but was more common on placebo. The incidence of diarrhea was similar between patients who received placebo and patients who received 30 mg of PREVACID, but higher in the patients who received 60 mg of PREVACID (2.9%, 4.2%, and 7.4%, respectively). Headache was also seen at greater than 1% incidence but was more common on placebo. The incidence of diarrhea was similar between patients who received placebo and patients who received 15 and 30 mg of Prevacid, but higher in the patients who received 60 mg of Prevacid (2.9, 1.4, 4.2, and 7.4%, respectively).